Early-Stage Development of BRET-Based Assays to Characterize the Activation of the Human Adhesion GPCR ADGRE5

Time: 9:45 am
day: Day One


  • Applying mechano-stimulation to study human ADGRE5 activation revealed by BRET-based biosensors
  • Demonstrating the mechanistic aspects of ADGRE5 receptor activation and impact on actin remodeling, exposing a possible mechanism by which hADGRE5 may promote tumor metastasis
  • Showcasing the future for the application of different technologies to study adhesion GPCR biology and develop screening assays to identify novel therapeutics targeting them in a pathophysiological setting