Alastair Corbin

Alastair Corbin

Company: Pathios Therapeutics

Job title: Senior Scientist


Inhibition of Acid Sensing by Allosteric Modulation of GPR65 Normalises Gene Expression in Primary Macrophages, Increases Natural Killer Cell Infiltration in Subcutaneous MC38 Tumors, and Restricts Tumor Growth 3:45 pm

Displaying how high frequencies of Tumor-Associated Macrophages (TAMs) are associated with poor patient prognosis • Leveraging the fact acidic conditions of the tumor microenvironment suppress macrophage immune function and support a pro-tumor TAM state Demonstrating how TAMs sense low pH through G-Protein Coupled Receptor 65 (GPR65) Utilizing Pathios compounds to inhibit GPR65 sensing of pH…Read more

day: Day Two

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