Francis Willard

Francis Willard

Company: Eli Lilly

Job title: Research Advisor

Seminars:

Novel Pharmacology Approaches to GPCR Allosteric Modulation 2:00 pm

Allosteric modulation of GPCRs is a promising approach for drug discovery The structural biology revolution has illuminated the basis for GPCR allosteric modulation by small molecules Describe the pharmacological and structural mechanisms of novel Class B GPCR allosteric modulators Discuss if current pharmacology models are sufficient to describe GPCR allosteric modulationRead more

day: Pre Conference Focus Day

Panel Discussion: Biased Signaling: From Pharmacology to Physiology 12:00 pm

GPCR signaling can be activated in a ‘biased’ response, via G proteins or β-arrestins with distinct biochemical and physiological actions from each other. The current field however requires further clarity to evaluate biased signaling from pharmacology to physiology for the benefit of discovering biologically relevant GPCR targets. From determining bias specificity to rationally designing biased…Read more

day: Pre Conference Focus Day

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