Design and Development of QMD Driven Physiological Biomolecular GPCR Small Molecule Agonist Complexes
Time: 11:15 am
day: Conference Day Two
Details:
- Peptides physiological confirmation, binding mode, design of peptidomimetics & to constraining peptidomimetics into peptides utilizing unnatural amino acids, we can develop orally agents. Further profiling against several GPCRs as targets for selective and stable peptides treating metabolic diseases
- Generate natural peptide sequence stable conformer, search for amidic back-bone, alpha C, acid and amine mimetic functional groups in to peptidomimetics. Covert peptidomimetics scaffolds region constrains to serve as small molecules for oral delivery
- Biolexis MolecuLern methodology employed in design of selective, oral, small, molecule agonists of GLP-1R, a class of GPCR agonists will be discussed
