Fireside Chat: Uncovering Tools to Discover Synthetic Ligands for Orphan GPCRs to Advance the Development of Effective Therapies
Time: 9:30 am
day: Conference Day Two
Details:
- How to begin tackling orphan receptors with little known pharmacology to discover their functional roles?
- What tools do we have to identify the signaling pathways, downstream effects, and mechanisms of action of orphan GPCRs to understand their therapeutic relevance?
- Is there a need to always discover a ligand against an orphan GPCR and can we work off signatures in the data instead?
- How to biochemically and biophysically characterize and validate orphan GPCRs for drug discovery?
