Unlocking Strategies to Identify Ligands that Activate Orphan GPCRs to Develop Agonists
Time: 9:00 am
day: Conference Day Two
Details:
- Developing and optimizing novel methods to identify endogenous and synthetic ligands acting on GPCRs to allow for the design of targeted GPCR therapies
- Application of the novel Gz-Enhanced Signal Transduction assaY (GzESTY) for identifying orphan GPCR ligands in complex tissue extracts and compound libraries
- Development of novel screening assays for the rapid identification of inverse agonists targeting GPCRs and orphan GPCRs
