Activation of the RXFP1 Relaxin Receptor By Diverse Agonists
- RXFP1 is a GPCR involved in cardiovascular and renal adaptation to pregnancy
- Using Cryo-EM, we determined the structure of this receptor bound to native relaxin hormone as well as the small molecule drug candidate AZD5462
- The two ligands bind different surfaces on the receptor and induce divergent signaling outputs