Beyond Incretins – Smarter Drug Design for Non-Incretin GPCRs: Innovative Screening & Computational Strategies for Next-Gen Allosteric Modulators
- Discovering high-throughput and functional screening methods for identifying allosteric modulators
- How can we quantify efficacy, cooperativity, and pathway-specific modulation and use AI/ML to predict allosteric sites and optimize ligand properties?
- Case studies of allosteric GPCR modulators progressing to the clinic and how they’ve overcome side-effect profiles, exploited subtype selectivity and modulated complex signaling