Functional Screening of AI-Designed Peptide Library Identifies Novel Opioid GPCR Agonists

• The description of a Functional Screening platform that combines high-throughput microfluidics with ultra-large DNA-encoded peptide libraries to generate rich activity datasets at scale
• The application of the platform to an AI-designed peptide library targeting μOpioid Receptor 1: rapidly identifying novel agonists with strong specificity and potency
• We present our screening approach, assay methodologies, and cell-based validation to demonstrate how Orbit’s platform efficiently translates computational designs into experimentally verified therapeutic hits 

Speakers:

Neil Butt

Chief Executive Officer

Orbit Discovery