GPCR Signaling Models for Mechanism-Driven Drug Discovery
- Disentangling intrinsic, system, and kinetic bias using time-resolved signaling assays combined with mechanistic mathematical modeling to provide a clearer, more reproducible and more predictive view of GPCR signaling
- Linking extended signaling parameters, beyond traditional potency and efficacy, to downstream functional effects to identify the optimal signaling profile for therapeutic efficacy and tolerability
- Enabling more efficient small-molecule design and optimization by connecting mechanistic signaling insights directly to chemistry and SAR