Harnessing a Highly-Selective Designer Protein Platform to Identify Agonists, Antagonists & Inverse Agonists for GPCR Targets
Time: 9:30 am
day: Conference Day One
Details:
- Engineering of a ‘hyper-stable,’ non-cross reactive human protein with hypervariable binding loops to selectively bind GPCRs
- Development of a robust platform to screen libraries of ligands for GLP-1R and cannabinoid receptor CB2R
- Functional characterization of agonists, antagonists, and inverse agonists for therapeutic development
