Pharmacological Characterization of Novel 5-HT2A Receptor Agonists with Non-Hallucinogenic Potential Using Translationally-Relevant Models & Neural Circuit Evaluation
- Characterization of 5-HT2A/2C agonists using functional assays capture the pharmacological effects that relate to behavioral modification and translationallyrelevant antidepressive effects
- Embracing concept of “targeted polypharmacology” rather than single-target approaches may allow neural circuit modulation which may be important in depression and substance use disorders
- Integrating circuit-level and behavioral insights into lead optimization strategies of 5-HT2A/2C agonists may help fine-tune polypharmacological modulation of dynamic neural systems