Revealing the Dynamic Pathways of GPCR Bias Through Integrated Modeling & Pharmacology to Accelerate Discovery of Functionally Selective Therapeutics
- Utilising AI and physics-based simulations to reveal conformational signatures behind G-protein vs β-arrestin signaling
- Integrate simulations with pharmacology to turn conformational insight into measurable biological outcomes
- Sharing case studies translating structural insights and pharmacology predictions into the discovery of biased GPCR candidates