Roundtable Discussion: Leading Deorphanization with the Identification of Endogenous Ligands as a Compound to Advance Rationale Drug Development
Time: 3:30 pm
day: Day One PM
Details:
- How to validate proposed true orphan GPCR-ligand pairs and with what suite of assays?
- What are the emerging methods for accomplishing deorphanization? Structural characterization, Mass spec etc
- How to reveal the therapeutically relevant signaling pathways activated by orphan GPCRs?
