Roundtable Discussions: Evaluating Emerging Approaches to Define the Future of GPCR Drug Discovery

Roundtable A: Comparing AI-Enabled & Experimental Screening Approaches to Improve GPCR Hit Identification

1. Where does AI outperform traditional screening workflows today?
2. When does experimental screening still provide superior biological insight?
3. What combination of computational and experimental approaches creates the highest-quality hits?

Roundtable B: Reconciling Structural, Computational & Functional Approaches to Characterize GPCR Conformational States

1. Where does Cryo-EM deliver the clearest actionable insight, and where does it fall short?
2. When does computational/ dynamic modelling genuinely outperform a static structure?
3. How do functional assay signals get reconciled with structural predictions when they disagree?