Transforming the Development of Functional Anti-GPCR Antibodies with AI-Driven Design
- Leveraging AI-driven design antibodies against GPCRs without immunization or display, including targeting deep intra-pocket epitopes previously inaccessible to conventional methods
- Generating large panels of GPCR-binding antibodies in a single computational run, achieving high hit rates and experimentally light workflows that validate both binding and functional activity in high relevance settings
- Demonstrating AI-enabled functional design, including agonism, antagonism, and ligand-mimicking behaviours, and highlighting why this represents a step-change for GPCR drug discovery