Unlocking G-Protein Subtype Bias at D1 Receptors to Drive Enhanced Pharmacological Effects
- Creating BRET-based assays that distinguish true Gs versus Golf engagement, enabling accurate measurement of receptor–G-protein coupling without downstream signaling noise
- Linking Golf-biased D1 activation to enhanced striatal electrophysiology and improved motor performance, demonstrating how molecular bias translates into region-specific physiological effects
- Delving into the mechanistic differences between Gs and Golf activation and their pharmacological consequences, which may lead to translatable strategies for targeting desired neurological effects