Hideaki Yano
Assistant Professor Northeastern University
Dr. Yano is an assistant professor in the Department of Pharmaceutical Sciences and Center for Drug Discovery at Northeastern University. Dr. Yano has investigated mechanisms of functional selectivity, allosterism, superagonism in GPCRs. He is currently examining these themes in the context of dopamine receptor and cannabinoid receptor pharmacology. He has developed tools to study these mechanisms and has identified previously unappreciated forms of signaling bias among G protein subtypes. These biases extend to electrophysiological and behavioral levels, providing a therapeutic proof-of-concept.
Seminars
Wednesday 29th April 2026
Unlocking G-Protein Subtype Bias at D1 Receptors to Drive Enhanced Pharmacological Effects
11:00 am
- Creating BRET-based assays that distinguish true Gs versus Golf engagement, enabling accurate measurement of receptor–G-protein coupling without downstream signaling noise
- Linking Golf-biased D1 activation to enhanced striatal electrophysiology and improved motor performance, demonstrating how molecular bias translates into region-specific physiological effects
- Delving into the mechanistic differences between Gs and Golf activation and their pharmacological consequences, which may lead to translatable strategies for targeting desired neurological effects
Wednesday 29th April 2026
Panel Discussion: Assessing the Pharmacological Impact of Biased Signaling, Endosomal Pathways & Oligomerization to Demystify GPCR Complexity
12:00 pm
- What are the innovative methodologies to study biased, endosomal, and oligomeric GPCR signaling?
- How can we establish best practices for interpreting complex signaling data and distinguishing true pharmacological effects?
- How to translate mechanistic insights into improved GPCRs-targeted drug discovery and development
