John Janetzko
Assistant Professor University of Colorado Anschutz Medical Campus
John Janetzko, Ph.D., is an Assistant Professor of Biochemistry & Molecular Genetics, Pharmacology, and Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus. His laboratory uses cryo-electron microscopy and single-molecule biophysics, together with protein engineering and cell-based approaches, to define the molecular mechanisms governing GPCR signaling, trafficking, and regulation. His research focuses particularly on the assembly and dynamics of GPCR-β-arrestin complexes and on leveraging mechanistic insights to develop new strategies for targeting disease-associated GPCRs. Prior to joining the University of Colorado, he trained with Nobel Laureate Brian K. Kobilka at Stanford University and obtained his Ph.D. in chemistry from Harvard University.
Seminars
- Developing functional nanobody binders to enable mechanistic studies of orphan GPCRs that remain difficult to interrogate using conventional pharmacological tools
- Using computational protein design to target receptors lacking experimental structures
- Integrating cryo-EM, microscopy, surface plasmon resonance, and cell-based assays to validate nanobody binding, define mechanism, and establish receptor pharmacology
