Jörg Bentzien
Director - Computational Chemistry Alkermes plc
Jörg Bentzien is Director of Computational Chemistry at Alkermes, where he applies advanced computational approaches to accelerate drug discovery and candidate optimization. With more than 25 years of experience spanning small molecules, biologics, machine learning, and in silico ADMET modeling, he has successfully supported multiple programs from early discovery through clinical development. Prior to joining Alkermes, Jörg held scientific leadership roles at Boehringer Ingelheim, FORMA Therapeutics, and Xencor, contributing to drug discovery efforts across GPCRs, ion channels, kinases, and immunology and cardiometabolic targets. He completed postdoctoral training in computational chemistry under Nobel Laureate Arieh Warshel at the University of Southern California and is an inventor on multiple patents and author of more than 25 scientific publications.
Seminars
- Applying structure-guided design principles to optimize potency, selectivity and druglike properties
- Overcoming medicinal chemistry challenges associated with targeting the Orexin 2 receptor
- Translating receptor biology and pharmacology into a development candidate for narcolepsy