Makaía Papasergi- Scott
Assistant Professor University of Rochester Medical Center
Makaía M. Papasergi-Scott, Ph.D. is an Assistant Professor at the University of Rochester Medical Center leading a research program that applies cryo‑EM and pharmacological approaches to unravel GPCR signaling and accelerate therapeutic target discovery. Her team also develops next‑generation cryo‑EM technologies to overcome barriers in structural biology.
Seminars
Wednesday 29th April 2026
Capturing Dynamic Structural Changes to Reveal Mechanistic Insights in GPCR Function & Ligand Binding
4:45 pm
- Integrating time-resolved data with molecular simulations to capture transient conformational states and predict functional outcomes
- Linking structure to functional mechanism by demonstrating how G protein activation correlates with allosteric structural rearrangements in the receptor and the ligand binding pocket, providing actionable insights for drug discovery
- Observing how ligand binding sites evolve during receptor activation, moving beyond static snapshots to understand dynamic GPCR behaviour
