Neil Butt
Chief Executive Officer Orbit Discovery
Seminars
Thursday 30th April 2026
Functional Screening of AI-Designed Peptide Library Identifies Novel Opioid GPCR Agonists
11:30 am
- The description of a Functional Screening platform that combines high-throughput microfluidics with ultra-large DNA-encoded peptide libraries to generate rich activity datasets at scale
- The application of the platform to an AI-designed peptide library targeting μOpioid Receptor 1: rapidly identifying novel agonists with strong specificity and potency
- We present our screening approach, assay methodologies, and cell-based validation to demonstrate how Orbit’s platform efficiently translates computational designs into experimentally verified therapeutic hits
