Ye Che
Senior Director GSK
Seminars
Thursday 30th April 2026
Designing Potent, Orally Available Cyclic Peptides as GPCR Modulators
11:40 am
- Accelerate GPCR structural determination and structure-based drug design with Cryo-EM combined with GPCR conformational stabilization.
- Integrate free-state and receptor-bound conformational data to engineer high-affinity macrocyclic peptides as GPCR modulators.
- Apply two complementary strategies to achieve oral bioavailability in preclinical animals
