Zsofia Lengyel Zhand
Principal Scientist Pfizer
Zsófia Lengyel-Zhand, Ph.D. is a Principal Scientist in Discovery Biology and Pharmacology at Pfizer. She earned her Ph.D. in Chemistry from Syracuse University and completed postdoctoral training at the Perelman School of Medicine at the University of Pennsylvania. At Pfizer, she serves as a portfolio lead for DNA-encoded library screening campaigns and collaborates across biology, chemistry, and data science teams to advance novel therapeutic programs. Her work combines innovative screening technologies with data-driven approaches to accelerate the identification and validation of new drug candidates.
Seminars
Wednesday 3rd March 2027
Navigating the Complexities of GPCRs in DNA-Encoded Library Screening
1:15 pm
- Addressing the unique challenges of applying DNA-encoded library screening to dynamic, conformationally complex GPCR targets
- Developing protein reagents and stabilization strategies to generate ligand-free GPCRs in active conformation, suitable for DEL screening
- Advancing DEL binders into functional chemical tools and agonists through iterative screening and orthogonal pharmacological validation
