Discovery of Clinical Candidate AZD5462, an Allosteric Oral Small Molecule Agonist for the Treatment of Heart Failure

Time: 9:30 am
day: Day Two AM


  • Reviewing the optimization of small molecule agonists of the Relaxin Family Peptide Receptor (RXFP1) resulting in discovery of AZD5462
  • Exploring mechanism of action and signaling in vitro and in vivo
  • Demonstrating the efficacy of AZD5462 in non-human primates