Navigating the Complexities of GPCRs in DNA-Encoded Library Screening
1:15 pm - Wednesday 3rd March 2027
- Addressing the unique challenges of applying DNA-encoded library screening to dynamic, conformationally complex GPCR targets
- Developing protein reagents and stabilization strategies to generate ligand-free GPCRs in active conformation, suitable for DEL screening
- Advancing DEL binders into functional chemical tools and agonists through iterative screening and orthogonal pharmacological validation
