Targeting Intrinsically Disordered GPCR Regions to Unlock New Opportunities for Selective Therapeutic Design

• Leveraging structural and computational approaches to characterize intrinsically disordered regions that regulate GPCR signaling and selectivity
• Exploring antibody-based strategies to target receptor-specific intracellular regulatory elements across orphan and disease-relevant GPCRs
• Establishing new approaches to improve therapeutic selectivity by modulating GPCR function beyond traditional extracellular binding sites

Speakers:

Sivaraj (Shiv) Sivaramakrishnan

Professor & Head, Genetics Cell Biology & Development

University of Minnesota - Twin Cities