Uncovering Super-Dark GPCR Biology to Expand the Druggable Receptor Landscape Beyond Known Targets

• Leveraging AI-driven structural comparisons to identify previously unrecognized GPCR-like proteins hidden beyond sequence similarity
• Applying experimental biology to validate computational predictions and establish novel receptor functions
• Expanding the future GPCR target landscape by illuminating “dark” and “super-dark” biology inaccessible through conventional discovery approaches

Speakers:

Daniel Isom

Associate Professor of Molecular & Cellular Pharmacology

University of Miami School of Medicine