Pros & Cons of Positive Allosteric Modulation in GPCR Drug Discovery – Case Studies from Lilly Research Labs
Time: 11:30 am
day: Day One Track B AM
Details:
- Discussing the attributes of a target that make allosteric modulation a desirable MOA for drug discovery
- Importance of profiling and understanding the key parameters of allosteric modulation (affinity, alpha, and beta) and their impact on target product profile
- Emerging importance of GPCR structural biology in the design and optimization of allosteric modulators
