Pros & Cons of Positive Allosteric Modulation in GPCR Drug Discovery – Case Studies from Lilly Research Labs

Time: 11:30 am
day: Day One Track B AM


  • Discussing the attributes of a target that make allosteric modulation a desirable MOA for drug discovery
  • Importance of profiling and understanding the key parameters of allosteric modulation (affinity, alpha, and beta) and their impact on target product profile
  • Emerging importance of GPCR structural biology in the design and optimization of allosteric modulators